WebProstate tumor cells, which characteristically metastasize to bone, initiate binding interactions with bone marrow endothelium under blood flow conditions through binding … WebNov 15, 2000 · The most characterized selectin ligand is P-selectin glycoprotein ligand-1 (PSGL-1), which was initially identified as a ligand for P-selectin, 8, 9 but is also reported …
Anti-P-Selectin Glycoprotein Ligand-1 Antibody, clone KPL-1 - Sigma-Aldrich
The primary ligand for P-selectin is P-selectin glycoprotein ligand-1 (PSGL-1) which is expressed on almost all leukocytes, although P-selectin also binds to heparan sulfate and fucoidans. PSGL-1 is situated on various hematopoietic cells such as neutrophils, eosinophils, lymphocytes, and monocytes, in which it mediates … See more P-selectin is a type-1 transmembrane protein that in humans is encoded by the SELP gene. P-selectin functions as a cell adhesion molecule (CAM) on the surfaces of activated See more P-selectin is located on chromosome 1q21-q24, spans > 50 kb and contains 17 exons in humans. P-selectin is constitutively expressed in megakaryocytes … See more P-selectin plays an essential role in the initial recruitment of leukocytes (white blood cells) to the site of injury during inflammation. When endothelial cells are activated by … See more • Selectin See more P-selectin is found in endothelial cells and platelets where it is stored in Weibel-Palade bodies and α-granules, respectively. In response to … See more P-selectin has a functional role in tumour metastasis similar to E-selectin. P-selectin is expressed on the surface of both stimulated … See more Crizanlizumab is a monoclonal antibody against P-selectin. which has now been approved by Novartis on November 15, 2024 for the indication of vaso-occlusive crisis in sickle cell patients. See more WebMar 24, 2024 · Using flow cytometry we analyzed in healthy donors and patients the expression of P-selectin Glycoprotein Ligand-1 (PSGL-1) in circulating neutrophils and the implication of PSGL-1/P-selectin interaction in neutrophil … spongebob intro turkish christmas who
The metastatic T− cell hybridoma antigen/P− selectin glycoprotein …
WebAug 28, 2001 · P-selectin is a member of the selectin family of adhesion molecules. PSGL-1 on the plasma membranes of neutrophils or monocytes, which are key effector cells of the innate immune system, binds to P-selectin translocated to the surfaces of inflamed endothelial cells or activated platelets (Fig. 1 ). WebP-selectin glycoprotein ligand-1 and L-selectin have roles in neutrophil recruitment and activate human endothelial colony-forming cells at the site of vessel injury; Taken … WebAug 9, 2024 · P-selectin glycoprotein ligand 1 (PSGL-1) is coded by a human gene called Selectin P ligand, also known as SELPLG. The protein is also referred to CD162. PSGL-1 is … spongebob invasion of the patty stealers